Alpha-gene triplication is a common co-factor that may convert a thalassemia trait to a disease or worsen a benign mutation. What are the Symptoms of Thalassemia? There are two subtypes of the disorder (alpha and beta) depending on what portion of the hemoglobin is abnormally synthesized. Thalassemia symptoms depend on the type of thalassemia you have and the severity of the anemia. [ citation needed ] Hemoglobin S /thalassemia: common in African and Mediterranean populations, is clinically similar to sickle-cell anemia , with the additional feature of splenomegaly . People who have thalassemia trait (also called thalassemia minor) carry the genetic trait for thalassemia but do not suffer from any health problems except a mild anemia. If it does, it causes minor anemia. If one parent has the cis form of alpha thalassemia trait (αα/--), and the other parent is a silent carrier (αα/α-), there is a 25 percent (1 in 4) chance with each pregnancy of having a child with hemoglobin H disease. It inhibits the production of hemoglobin and red blood cells. Learn more about thalassemia, also known as Mediterranean Anemia, Cooley's Anemia or Homozygous Beta Thalassemia, and possible signs, symptoms, and treatment options for both thalassemia trait and tha General Symptoms of Thalassemia. A person may have either alpha thalassemia trait or beta thalassemia trait, depending upon which form of … Symptoms of thalassemia. Your symptoms will depend on the category of thalassemia you have. People who have alpha thalassemia trait have red blood cells that are smaller (microcytic) and paler (hypochromic) than normal, have a decreased MCV (mean corpuscular volume, a measurement of the average size of a single red blood cell), and have a mild chronic anemia. Alpha Thalassemia Minor, also called Alpha Thalassemia Trait (2 genes affected). Thalassemia is an inherited blood disorder. For moderate to severe thalassemia, treatments might include: Frequent blood transfusions. Other people have mild to severe symptoms. Hemoglobin E/thalassemia: common in Cambodia, Thailand, and parts of India, it is clinically similar to β thalassemia major or thalassemia intermedia. Thalassemia minor generally doesn’t cause any symptoms. Some such cases result from an autosomal dominant form of thalassemia and others from inheriting a mutation that is not detected by the probes utilized in the DNA testing. fatigue Beta Thalassemia trait: Introduction. More severe forms of thalassemia often require frequent blood transfusions, possibly every few weeks. Beta-thalassemia. Mild forms of thalassemia trait don't need treatment. Symptoms of thalassemia may include one or more of the following: Paleness. This is why it is also sometimes referred to as Mediterranean anemia. It leads to a decrease in overall hemoglobin levels, with the characteristic signs and symptoms of anemia.. Signs and symptoms of alpha thalassemia are those of other types of anemia and include. For example, people affected by milder forms of thalassemia can develop mild anemia or may have no signs or symptoms of the condition at all. Beta Thalassemia trait: Thalassemia is an inherited blood disorder characterized by abnormal synthesis of hemoglobin. A person may have alpha or beta thalassemia, and symptoms … Intermediate forms of thalassemia can cause mild to moderate anemia and may be associated with other health problems such as slowed growth, delayed puberty, bone … Some people have little or even no symptoms. Tiredness, low energy, or muscle weakness (also called fatigue). 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