Silybin predominates, followed by silydianin and silychristin. Name of the medicinal product. Milk thistle, Silybum marianum, is a tall edible plant and a member of the Aster family. Modern Medicinal Use. Beauty & Radiance Support, Digestive Support, Liver & Cleanse Support. Silybum marianum (L.) Gaertner, fructus extract (according to HMPC Monograph) Other Notes Certified for the analytes listed below. It is a stout, annual or biennial plant which can reach heights of 6 feet. Alternative Medicine Review Monographs Silybum marianum Description Silybum marianum (milk thistle) has been used for centuries as an herbal medicine for the treatment of liver disease. Plant Finder Database: Silybum marianum (Plant Finder, 12 November 2019). Milk Thistle Monograph: (Silybum marianum) Alternative Medicine Review 1999 (Aug); 4 ( 4): 272–274 ~ FULL TEXT Silybum marianum (milk thistle) has been used for centuries as an herbal medicine for the treatment of liver disease. In a study investigating the effects of this formula, by looking closer at the impact of the single extracts included, found that C. scolymus was able to … Silybum marianum . blessed milkthistle. To retrieve all information on milk thistle (Silybum marianum), including data published post-approval, use the all studies query. Qualitative and quantitative composition 1, 2 Saller R, Brignoli R, Melzer J, Meier R. An updated systematic review with meta-analysis for the clinical evidence of silymarin. Silybum marianum has been found to offer protective benefit against substances including carbon tetrachloride, ethanol, paracetamol-induced liver peroxidation cyclosporin, phenothiazine, a butyrophenone, erythromycin, amitriptyline and nortriptyline oestradiol, Amanita phalloides, tacrine, Iron overload [3]. Silymarin is found in highest concentrations in the fruit portion of the plant but is also found in the leaves and seeds. The species is hermaphrodite (has both male and female organs) and is pollinated by Bees. Plants for a Future Database: Silybum marianum (Plants For A Future, 12 November 2019). Missouri Botanical Garden. St. Louis, MO 63110 USA. Preliminary evidence suggests milk thistle may reduce side effects such as hepatotoxicity, nephrotoxicity, radiation-induced mucositis and dermatitis, … DIDB drug monograph DDI summaries are composed when the drugs are first approved by the FDA and are based on data curated mainly from NDA reviews and drug labels. Milk thistle is considered a weed by most gardeners because of how fast it grows. Ingredient Type:Botanical, Extract Also Known As: Silybum marianum extract, Silymarin, Mary thistle extract, Holy thistle extract Silybum marianum or milk thistle is a plant from the Asteraceae family, native to Southern Europe, parts of the Middle East, and Northern Africa. It is hardy to zone (UK) 7 and is not frost tender. European Union herbal monograph on Silybum marianum (L.) Gaertn., fructus 1. Its use for liver disorders dates back to Pliny the Elder, a Roman naturalist, who described Milk thistle herbal preparations are produced from the seeds of Silybum marianum (L.) Gaertn. Silymarin includes the individual flavonolignans silybin A and silybin B (two isomers, together referred to as silibinin 4), isosilybin A and isosilybin B (two isomers), silydianin, and silychristin. In Germany, milk thistle seed extracts have been marketed for many years. The white veins found on the leaves were thought to represent the Virgin Mary's milk and therefore was used as a galactagogue . * Traditional Health Benefits of Milk Thistle. The plant originates from mountains of the Mediterranean region, where it forms scrub on a rocky base. milk thistle. Intensive research in the hepatoprotectant (liver protecting) effects of milk thistle began about 40 years ago. 2. Silybum marianum has the energetics of a dry temperament, capable of removing obstructions through sweating and cleansing of the pores. It is in leaf all year, in flower from July to September, and the seeds ripen from August to October. See certificate for values and more details Phytochemicals: Silybin A+B (quantitative); Silicristin, Silidianin, Isosilibinin A, Isosilibinin B (qualitative) The efficacy of Silybum marianum (L.) Gaertn. Botanical Monographs The seed of the Milk Thistle ( Silybum marianum ) plant was considered a specific for stitches in the side. 2006;20(12):1036-9. The Legalon extract of Silybum marianum is known as MZ 80 and has been extensively researched over the past few decades to support liver health. Accepted for publication January 6, 2015. These herbs include Cynara scolymus, Taraxacum officinale, Silybum marianum, and Peumus boldus. 2005. Out of scope information includes radiopharmaceuticals, contrast media, herbals, homeopathics, and food. Silybum marianum. It has a shiny brown stem, 1-3 feet high, with several branches and prickly thorns. Silymarin also contains fatty acids 5 and a flavanone dihydroquercetin (taxifolin), 6 also credited with medicinal effects. Silybum marianum – St Mary’s Thistle Monograph (PDF link) Great work Maureen, and again, congratulations! To be specified for the individual finished product. It has been studied for use in allergic rhinitis, asthma, cancer treatment–related adverse effects, rheumatoid arthritis, type 2 diabetes, drug-induced hepatotoxicity, drug-induced nephrotoxicity, dyslipidemia, and thalassemia; however clinical trials supporting these uses are limited. Silybum marianum is a medicinal plant whose therapeutic his-tory dates back to 2000 years ago and was used as a hepatopro-tective medication to treat jaundice and enlarged liver and spleen. The fruit is a strongly compressed, elongate-obovate achene, about 6 to 8 mm long, 3 mm broad and 1.5 mm thick. Herbal Monograph. [Fam. Application Number or Monograph Citation Marketing Start Date ♦ provide a model monograph as a basis for countries and researchers to develop further monographs on good agricultural and collection practices (GACP) for other medicinal plants; ♦ protect the wild resources of medicinal plants, in particular Artemisia annua L., to ensure their sustainable use. variegated thistle. Formulations made with the seed of the plant are used to address biliary digestive complaints, toxic liver damage, and supportive treatment in chronic inflammatory liver disease and hepatic dirrhosis. The monograph on Silybum marianum (St Mary’s Thistle or Milk Thistle) can be seen listed on the most recent ANPA Newsletter, and I have also attached the full monograph below (with permission from Eta Brand, ANPA President and Editor). Milk thistle (Silybum marianum) is a thorny plant presenting decorative leaves with a white pattern of veins and purple flower heads. 2: Fructus Silybi Mariae. Silybum marianum is a BIENNIAL growing to 1.2 m (4ft) by 1 m (3ft 3in) at a fast rate. Milk thistle has been investigated for its anti-inflammatory, antimicrobial, and CNS effects. It has been naturalized in South America, North America, and Southern Australia and requires warm, dry soil to grow (1). Plant Description: Milk Thistle (Silybum marianum) is generally found in dry, rocky soils in southern and western Europe and is commonly seen in California. Herbal monograph for Milk thistle includes parts used, how to use as an herbal medicine, dosage and contraindications. In the U.S. in 2000, milk thistle ranked 11th in sales of all herbal products sold in food, drug, and mass market outlets, reaching about $9 million in retail sales. Silymarin counteracts the toxic effects of a wide variety of liver poisons, including alcohol, carbon tetrachloride (used widely in the dry-cleaning industry) acetaminophen and the death cap mushroom, which can cause death within a day. 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